Comparison The Effect Of Dexamethasone On The Blood Glucose Level Between Pregnant Versus Non Pregnant Females Under General Anesthesia

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Ali Hassan Jabbar, HANAN FAWZI MOHAMMED MOHAMMED

Abstract

Background: Dexamethasone prevent postoperative nausea and vomiting. In spite of this advantage, it found that injection of intravenous (IV) dexamethasone direct affect the blood glucose. We compared blood glucose concentrations after intravenous injection of dexamethasone in the pregnant and non-pregnant women under general anesthesia.


Aim of study: to compare the effect of dexamethasone on the blood sugar levels and about its safetyespecially in the pregnant women.


Patient and method: Eighty patients aged 18-50 years. ASA class 1 and 2.Forty of patients undergoing elective cesarean section under G/A and the other forty undergoing elective laparoscopic Cholecystectomy under G/A. anesthesia was induced by using IV anesthetic drugs (0.5mg/kg ketamine, sleeping dose of propofol up to 2mg/kg, muscle relaxant was 0.6 mg/kg rocuronium and maintained with isoflurane). All of patients have injected with 0,1mg/kg dexamethasone intravenously, at induction of anesthesia, Blood glucose concentrations measured at induction and then at 60min, 180min and at 360 min after injection of dexamethasone and compared between the groups, IV fluid was normal saline (0.9%) during the study.


Result: Regarding to blood glucose levels, we noticed that significantly increase over time and peaked at 180min after dexamethasone injection in both group. The difference percentage between the lower reading (pre injection) and  the upper reading(at 180min) was 33.5% for pregnant woman and 46.2%for non-pregnant women, this difference was statistically significant relative to the pre injection , as we see this difference was lower in the pregnant women. At 360min, blood sugar readings start to drop in both groups.Conclusion:After giving 0.1 mg/kg of dexamethasone, blood glucose increased in both groups but it was lower in the pregnant women.

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