Blood Pressure And Heart Rate For The Four Period Adaptation In ICR Male Mice

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Hanaa Abdulabbas, NeeranF. Hassan, AlyaaI. Aldebs

Abstract

Before starting blood pressure measurements in male mice, 16 h, 14, 28, 40 daysadaptation time is typically recommended. Nevertheless, sixdays after shipping, we saw hypertension CODA Monitor-Kent-Scientific) in ICR male mice. While starting blood pressure measurements in after 16 hr from transport14daysadaptation time issignificantly hypertension recommended compared with  control 40 days transport . Furthermore, 28days after shipping, we recorded mid hypertension in ICR male mice.The experimental  group (n = 10, 1 month ±5days old, weight (18–22 g) was delivered overnight by means of taxis, period 16 hr. Systolic blood from the tail cuff  method ( Coda monitor) mice have significantmild highblood pressure. Experiment group  were compared to three control groups (n = 10/group), one adapted for 14days after shipment, and second adapted for 28 days after transportation  third is housed mice until 40days after transportation. at least one acclimation period obtained from an inhouse colony When testing blood pressure in mice, it takes 18 weeks.Systolic blood pressure in the experiment group was 135±0.8 mm Hg one week after delivery. Because this was far greater than previously reported for this strain, acclimatization took longer. Systolic blood pressure had received the package 42days after it was shipped.fallen to 120 ± .03 mm Hg P < 0.05. Throughout this time, heart rate also fell from 531 ± 0.5in experimental group to 380 ± 0.2 bpm in 40 day housted male mice  P < 0.05. systolic blood pressure in the two control groups was also lower than in the experiment group 14 days  and 28 days after shipping, with the acclimated 129 ± 0.2 vs. 126 ± 0.6 mm Hg, and housed male mice 126±0.3 P < 0.05 respectively.

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