EVALUATION OF SALIVARY MATRIX METALLO PROTEINASE-13 AND TISSUE INHIBITOR OF METALLOPROTEINASE-1 LEVELS IN PATIENTS WITH CHRONIC PERIODONTITIS

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Widianto Meydhyono, Aini Hariyani Nasution, Syafruddin Ilyas, Irma Ervina, Ameta Primasari

Abstract

Background: Periodontitis is an infectious disease caused by specific microorganisms that cause inflammation and damage to the supporting tissues of the teeth. Increased Matrix Metalloproteinase (MMP) and decreased tissue inhibitors of metalloproteinase (TIMP) levels cause degradation of connective tissue collagen and alveolar bone. MMP-13 is an enzyme involved in periodontal tissue damage. TIMP-1 is known as inhibitor of MMP. Objective: The objective of this study was to show the comparison of MMP-13 levels and TIMP-1 levels in the saliva of patients with chronic periodontitis and healthy patients. Research Methods: The study samples were selected from patients who came for treatment at Periodontic Installation Universitas Sumatera Utara (USU). The selected patients were 16 patients with a diagnosis of chronic periodontitis and 16 healthy patients. MMP-13 and TIMP-1 level in saliva were tested using ELISA technique. Results: The results showed that salivary MMP-13 levels in chronic periodontitis patients were higher than those of in healthy patients and salivary TIMP-1 levels in chronic periodontitis patients were lower than those of in healthy patients with statistically significant difference(p <0.05). There was a positive correlation between clinical parameters and salivary MMP-13 levels in patients with chronic periodontitis and healthy patients but it was not statistically significant (p> 0.05). There was a negative correlation between clinical parameters and TIMP-1 levels of saliva in patients with chronic periodontitis and healthy patients but it was not statistically significant (p> 0.05). Conclusions: MMP-13 levels was higher and TIMP-1 levels was lower in chronic periodontitis patients compared to those in healthy patients.

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