Formulation, Development, Evaluation and Solubility Enhancement of Lercanidipine Hydrochloride by Inclusion Complex Method

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S.D.Mankar, Dr.Punit R. Rachh

Abstract

Background: Cyclodextrins (CDs) are a group of cyclic oligosaccharides compounds made up of glucopyranose units which are linked by (α-1, 4) linkage and obtained after enzymatic action on starch molecule.


Aims and objective: The objective of present study is to study the interaction of LER (LER) and Cyclodextrins (CDs) in terms of formation on inclusion complex.


Material and methods: The formation and conformation of the inclusion complex in the optimized inclusion complex was studied in detail by fourier-transform infrared spectroscopy (FT- IR), powder X-ray diffractometry (PXRD) and Proton nuclear magnetic resonance (NMR).


Result: Significant increase in the DE30 and MDT was obtained with the optimized inclusion complex. Result of FTIR, PXRD, 1H NMR and DSC confirms that strong interaction takes place between LER and HPβCD.


Conclusion: Physical mixing , kneading and freeze drying technique, freeze drying method is most successful in producing inclusion complex with faster and higher dissolution.

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