A Comprehensive Review on in Silico Computational Studies of Siddha Formulations Against Sars – Cov- 2

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V. Poorna Pushkala

Abstract

The global current scenario shows that COVID-19 has spread worldwide and drugs prescribed to treat the disease are under study. The imperative requirement of drugs to treat COVID-19 has made significant changes in the pharmacological industry. Discovering drugs for such a pandemic has been a crucial target, with standardisation, preclinical and clinical studies being conducted in all possible age groups. Siddha medicines have found their way in the treatment of COVID-19 largely and increasingly been accepted worldwide. Among such constant trials, implementation of the molecular docking process has helped to reveal the importance of different Siddha medicines in the first place as therapeutics to COVID-19. The Government bodies have also recommended these antiviral compounds to treat symptoms such as cold, fever, breathing difficulty and sore throat. This study aims to focus on to gather awareness on the impact of various Siddha medicines and their insights into molecular level to fight against Coronaviruses. As a result of this review, it was found that the phytochemical compounds present in various siddha medicines such as Kabasura Kudineer, Adathodai Kudineer, Maramanjal Kudineer and so on, have been docked with the possible target proteins of SARS-CoV-2 virus to disclose that they have potential action on the virus and declare to act as the candidate drugs in COVID-19 treatment.

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