Estimate Effect Of Ocimum Basilicum L. Seeds Extract On Lipid Profile & Minerals In Hypomagnesemic Of Female Rats

Abstract

The current study was performed to investigate the effect of the alcoholic extract of Basil seeds (Ocimum basilicum L.) in remission of metabolic syndrome in hypomagnesemia which is induced experimentally in female rats. Fifty female rats were randomly assigned to 5 equal groups and treated daily for 56 days as follows: Control group (G1) received tap water, hypomagnesemia group (G2) treated with KCl (1.39mg/kg Bw) orally, (G3) orally KCl (1.39mg/kg BW) orally with (250mg/kg BW) alcoholic extract of Basil seeds, group treated with (250mg/kg BW) alcoholic extract of Basil seeds (G4) Finally hypomagnesemia group treated with MgSo4 injection (0.1 mg/kg BW) (G5).  Fasting blood samples were collected by heart puncture technique at 56 days of experiment to assess the lipid profile (LDL-c, VLDL-c, HDL-c, total cholesterol and TAG) and Minerals. The result indicated that magnesium and calcium ion concentration decreased significantly in hypomagnesmia group and increased significantly in groups treated with oral alcholic basil seeds and injection MgSo₄. Potassium concentration:  Groups with oral intubation of basil seeds causes significant decrease in K⁺ as compared with hypomagnesmia group. In addition, MgSo₄ injection causes significant decrease in K⁺ concentration. Lipid profile (LDL-c, VLDL-c, total cholesterol and TAG) showed significant increase in group which treated with KCl only, while decrease in groups with oral intubation of alcoholic extract of basil seeds, also decrease in group with MgSo₄ injection. HDL-c level showed significant decrease in hypomagnesmia group which treated with KCl, while increase in groups with oral intubation of basil seeds, also MgSo₄ injection in show significant increase in HDL-c. The concluded that obtained from these results revealed that MgSo₄ supplementations are beneficial in returning the minerals to the normal level.