Albumin Binding Function And Endocan For Early Detection And Progression Of Early Stage Nonalcoholic Fatty Liver Disease (Nafld)

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M. Shareef , Hassan H. AL-Saeed, Fadhil Abdullah

Abstract

Background & Aims: Non-alcoholic fatty liver is one of the non-communicable diseases that has spread widely around the world during the recent period.Our aims wereDetermination of the levels of albumin binding function and endocan for early detection and progression of nonalcoholic fatty liver disease.
Methods: Study included 88 patients (29 NAFLD), (29 NASH) and (30 healthy as controls).The ELISA assay was used to determine the endocan serum level, ion metal binding capacity by spectrophotometer, and albumin binding capacity by spectro fluorescence.
Results: The serum level of endocan in control ,NAFLD and NASH were (0.41±0.06 ng/ml) (0.63±0.23 ng/ml) and (1.42±0.54 ng/ml) respectively, with a p value< 0.001 showing a significant difference and high level of endocan concentration in NAFLD and NASH compared with control. The serum level of IMAT in control, NAFLD and NASH were(0.63±0.11IU/L),(0.48±0.05 IU/L) and(0.37±0.07 IU/L) respectively, with a p value <0.001.The plasma levels of ABiC were (192.29±7.79), (170.54±12.29) and (149.81±13.83) respectively, and p value <0.001. The IMAT/Albumin ratios were (1.340.23), (0.920.19), and (0.810.11), with a p value of 0.001. The resultsshows there are significant differences between groups and shows low levels of IMAT ,ABiC andIMAT/Albumin in NAFLD, NASH in comparison with control groups .
Conclusions: Patients with NAFLD and NASH had significantly higher levels of serum endocan than the controls. The level of albumin binding function (IMAT, ABiC, and IMAT/Albumin ratio ) decreased significantly in NAFLD and NASH compared with controlbecause of impaired albumin in these pathologies.

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