Evaluation Of Adverse Drug Reaction On Different Body Organs In The Center Of Nuclear Medicine & Oncology – Bach Mai Hospital

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Nhan T. Tran , Le Vuong D. Tran , Thuc Bui Thi Ngoc , Thi Ngoc T. Bui , Thi Hong A. Tran

Abstract

Background: Combination chemotherapy is the gold standard in the treatment of advanced malignant neoplasms. Side effects of chemotherapy necessitate a deeper study of clinical manifestations in patients receiving chemotherapeutic agents. And the algorithms for systemic assessment and correction of emerging side effects must be created.


The main aim. To evaluate the monitoring, supervising, and reporting activities for adverse drug reaction (ADR) events in Bach Mai hospital.


 Materials and Methods: The retrospective study on ADR reports is presenteted. Data exploration steps included: assessing the situation of monitoring, monitoring and reporting ADR at Bach Mai Hospital. The сlassification ADR was made by the age group, route of injection and drugs using, clinical manifestations, affected body organs.


 Results: Bach Mai hospital has introduced the activities of monitoring, supervising, and reporting for ADR events in common. All units of the Bach Mai Hospital have carried out these activities with a total of 2074 ADR reports (0,58%). According to the reports, ADR occurs in all patient age groups. ADR met at all the route of drug administration, the ratio is the highest for oral introduction (32.08-37.24%). Each organ can be affected by ADR, in which disorders of the skin and subcutaneous tissue are the most commonly reported (53.18-58.03%). Almost ADR can recover completely (96.68-98.44%). There were no fixed deaths due to ADR.


 Conclusion: The number of ADR reports was inadequate compared to the large scale and potential of the hospital. ADR monitoring, detection, and reporting had been unsteady, the involvement of clinical pharmacists was still limited.

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