The Efficacy Of Mild Stimulation Protocol In In Vitro Fertilization In Haiphong Hospital Of Obstetrics And Gynecology From 1/2016 To 6/2017

Abstract

Objectives: To compare the efficacy of mild stimulation protocol versus short Antagonist protocol in in vitro fertilization in Haiphong Hospital of Obstetrics and Gynecology from 1/2016 to 6/2017.

Subjects and method: A randomized controlled clinical trial. A total of 100 patients in expected normal responders undergoing IVF/ICSI were divided into two groups: mild group (n=50) - receiving clomiphene citrate (50 - 100 mg/day for 5 days from the cycle day 2) with low doses of FSH daily (75-225IU/day from cycle day 7) and GnRH antagonist; Antagonist group (n=50).

Results: the duration of stimulation (7.98 ± 1.42 days vs 8.56 ± 1.43 days) and the total dose of FSH (1551 ± 399.14IU vs 2683 ± 590.45IU) were signiticantly less in the Mild group than in the Antagonist group (p < 0.01). The number of retrieved oocytes (11.34 ± 6 oocytes vs 11.72 ± 6.31 oocytes), fertilized oocytes (66.5% vs 73%) and clinical pregnancy rate (50 vs 42.6%) were similar in two groups (p > 0.05).

Conclusions: Mild ovarian stimulation seems to constitute an equally effective method as compared to the Antagonist protocol in expected normal responders undergoing IVF/ICSI.