Effect of Saba Banana Peel Extract (Musa paradisiaca L) On Incision Wound Healing in Mice (Mus musculus)

Abstract

Background: Wounds are damage that occurs to the body caused by a myriad of destructive factors. When a wound arises, a wound healing process will occur which begins with the bleeding process. The wound healing phase is divided into 4 phases, namely the hemostatic phase, inflammation, proliferation and remodeling. There are several ingredients that can affect wound healing such as flavonoids and tannins. Flavonoids and Tannin can be found in high levels in Saba banana peel, so it has the potential to be used as an agent to accelerate the wound regeneration process after extraction process. The mechanism of action of flavonoids and Tannin in wound healing is to inhibit the formation of inflammatory mediators excessively so that the inflammatory process can take place normally and the healing process can be accelerated. Research Objectives: The purpose of this study was to determine the effect of Saba banana peel extract (Musa paradisiaca L.) on incision wound healing in mice (Mus musculus). Research Methods: This study was a laboratory experimental study with a post-test only control group design. The test animals used were 27 male mice divided into three treatment groups according to the specified inclusion and exclusion criteria. This study was measured by looking at the time to heal incision wounds until the wound has closed. The collected data was then processed using the SPSS version 24 program. Results: Based on observations, it was found that in the povidone iodine group and Saba banana peel extract, the wound healed within 9 days, whereas within 9 days there was no healing in the aquadest group. Based on the data analysis it was found that the average healing time in the povidone iodine group was 2 mm and the Saba banana peel extract was 1.88 mm. Conclusion: Saba banana peel extract (Musa paradisiaca L) can accelerate the healing time of incision wounds in mice. Suggestion for further research is to do histopathological examination so that the results of the study can be accurate.