The Relationship Between Some Serum And Synovial Fluid Cytokines And Pain Level At The Early Stage Of Knee Osteoarthritis

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Viet Nam Nguyen, Quang Thuan Huynh, The Luc Dang, Van Ty Nguyen, Hanh Le, Ngoc Chau Nguyen

Abstract

Background: Some cytokines such as IL-1β, TNF-α, VEGF, IL-6, IL-15, IL-17, IL-18, IL-4, IL-10, and IL-13 had been found in the knee joint and demonstrated the correlation to knee injuries and clinical symptoms. Paint is the most important symptom in OA. However, the causes and correlative factors of paint in OA are still not clear.


 The main aim: To study the determination IL-1b, IL-6, IL8, and IL4 in serum and synovial fluid in the knee of osteoarthritis patients at the early stages and their relationship to pain level.


 Materials and Methods: A cross-sectional descriptive study was conducted in 35 knee osteoarthritis patients with knee effusion from April 2018 to July 2019 in Military Hospital 103. The serum and synovial fluid were used to determine the cytokines level and to estimate the correlation between them and some clinical features.


 Results: There were no significant differences between the cytokines levels in terms of age, gender, pain level as the visual analog scale score, and the duration of disease except IL4 in synovial fluid were differences between the visual analog scale score group and osteoarthritis stages. The interleukin levels in synovial fluid had a high correlation to each other. There was no significant correlation between their levels in the serum.


 Conclusion: In synovial fluid, only the IL4 concentration was significantly different between osteoarthritis stage and pain level groups.

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