The Effect Of Prealbumin On Liver In Rheumatoid Arthritis In Iraqi Patients

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Alaa A. Abdulrazzaq, Teba F. Hadi

Abstract

Rheumatiod arthritis (RA) is a long-term autoimmune disorder that represent by many symptoms like swollen and painful joints, as well as other organ may be affected like liver and other overlapping pathological and clinical manifestations. As a result, this disease can shows a great clinical challenges and many questions about diagnostic criteria for liver diseases .The present study was designed to investigate if the prealbumin effect in the liver progression in rheumatoid arthritis patients , so this study was accomplished in the department of Biology, Al-Rasheed University College, comprising of n= 80 subjects known rheumatoid arthritis patients with an age range 30 - 60 years and healthy controls n=80 with age range 30 - 60 years attending the Baghdad Teaching Hospital (Educational Laboratory), Al-Kindy Teaching Hospitaland Al-Imamian Al- Kadhimyain Medical City in Baghdad with disease duration was 6.5 ± 1.4 years. In this study somechemistry measurements included the (CBC) and  the levels of CRP protein and prealbumin were estimated to investigate their correlation with liver abnormalities in RA patients. The mean (± S.D.) serum CRP level in the control group was found to be 24.61 ± 7.60 while it expressed higher levels in RA patients 25.05± 51.19  and the mean (± S.D.)  serum prealbumin  level in the controls was found to be 210.3 ± 51.2 whereas in RA patients, its level  was found to be 168.2 ± 50.6  .This study suggested that c-reactive protein (CRP) could be a good inflammatory markers that were reported to have a fatal value for the valuation of systemic inflammatory disease and the serum prealbumin (PA)  concentration might be a more sensitive indicator in assessing liver abnormalities  in rheumatoid arthritis  patients.The present study was aimed to find the influence of prealbumin protein on liver sufficiency in rheumatoid arthritis patients.

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