The Role Of Chemerin In Iraqi Patients With Acute Coronary Syndrome

Abstract

Background: Coronary artery disease (CAD) is the principal aetiology underlying angina pectoris, myocardial infarction (MI) and cardiac failure secondary to ischaemia, and is a key factor associated with the position of cardiovascular disease (CVD) as the primary cause of fatality on a global scale ,novel marker chemerin has anti inflammation and cardiovascular protective role. Chemerin, which has the alternative nomenclature retinoic acid receptor responder 2 (RARRES2), tazarotene-induced gene 2 protein and RAR-responsive protein TIG2 is a proinflammatory adipokine expressed in abundance in white adipose tissue and hepatocytes. Encoded by the RARRES2 gene, it has been linked with the inflammatory process. 

Objective: To estimate chemerin levels in acute coronarysyndrome and find the prospect of use chemerin in diagnosis in ACS.

Patients and Methods: The study conduct with 80 patients and 58 control. The patients divided into two groups: (n=40) acute coronary syndrome, and (n=40) chronic stable angina, number of control (n=58).

Result: In this present study, observed that the mean age of patients with ACS was (61.25 years)and (62.65 years) chronic unstable angina cohort; and control group,( 59.87 years).The mean of Chemerin of ACS, chronic stable angina cohort; and control group, are 73.519, 51.20 and 3. 36.47 ng/mlrespectively, Chemerin titers was; elevated levels on admission were noted in individuals presenting with ACS compared to control subjects and reach their peak within few hours after ACS.

Conclusion: Acute coronary syndrome patients showed a significant elevation in serum chemerin compared with control group.Thus, it may be used in the appraisal of such patients., serum chemerin has cardiovascular protective role and can be used as adiagnostic biomarkers in patients with ACS.