Investigation Of Antidiabetic Activity Of Artrocarpus Altilis In Alloxan Induced Diabetic Rats

Abstract

An overview of the Antidiabetic activity of Atrocarpusaltilis seeds on alloxan induced diabetic rats is presented in this research work. The study aimed at evaluating antidiabetic activity of the ethanolicseed extract of A. altilisin alloxan-induced diabetic rats. Diabetes was induced in rats after overnight fast with 120 mg/kg alloxanintraperitoneally. After 72 h, those with plasma glucose levels >200 mg/dl were classified as diabetic. Six diabetic rats in each group were treated daily for 14 days orally with 250, and 350 mg/kg of the extract, glibenclamide(10 mg/kg), while another group was untreated. Control received 5 ml/kg of 0.9% saline solution.. Effects of extract on glucose, and body weight were evaluated. Percentage inhibition was determined.Diabetic control was achieved on the 7th day of the study with 250, and 350 mg/kg of the extract showing glucosereduction of 69.23% and 75.21%, respectively. This study showed that seeds ofA. altilishave antidiabetic activity.