Morphological Profile Of Mycobacterium Tuberculosis Bacteria In Positive Acid-Fast Bacillus (Afb) Patients During 4 Months Of Treatment

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Tuberculosis (TB) is a disease caused by the bacterium Mycobacterium tuberculosis. These bacteria are generally in the form of whole rods, but based on the experience encountered by several Health Analysts in microscopic examination of sputum, bacteria are often found that are not in general shape.Researchers are interested in knowing the differences in morphology of Mycobacterium tuberculosis bacteria microscopically in the sputum preparations of patients with positive smears every week for two months of treatment.This study used a quantitative type with an observational (non-experimental) research design. The research criteria are descriptive with the type of periodic series (time series). Subjects were sixteen TB patients with positive smears who were observed for bacterial morphology in sputum preparations every week, from suspect to 8th week after treatment by calculating the average size of bacteria and the percentage of bacterial damage.Bacterial size continued to decrease with increasing treatment time each week. Its size is reduced from 0.19 m – 0.49 m. Cell size decreased by an average of 46% with the smallest decrease at week 2 of 4% and the largest decrease at week six by 61%, before finally being undetectable again at week eight. every week from suspect to two months of treatment in the length range of 1.07 m – 1.40 m and the wide range of 0.35 m – 0.19 m. TB patients have experienced conversion or change from smear positive to smear negative after two months of treatment in the intensive stage. Bacterial cell damage from week to week, on average increased by 29% per week until finally negative at week 8 or two months after treatment.The conclusion from this study is that the size of the Mycobacterium tuberculosis bacteria showed changes with the time of intensive treatment with its size reduced from 0.19 m – 0.49 m. Cell size was reduced by an average of 46%. Bacterial cell damage from week to week, an average of 29% increase per week

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