Increasing the Efficiency of Laboratory Diagnostics of Infectious Diseases Using Innovative Technology of Ultrasonic Disintegration of Immune Complexes

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Dudnikov S. Y, Pastushenkov V. L, Mitin Y. A, Li R. V, Shapovalov S. V

Abstract

The problem of increasing the efficiency of laboratory diagnostics of infectious diseases using innovative technology of ultrasonic disintegration of immune complexes is considered. The innovation of the technology lies in the application of ultrasonic action on the sample using a dispersant at the stage of preanalytical preparation in order to destroy circulating immune complexes, which leads to an increase in the amount of free antibodies and antigens in the sample. During the study, the technological parameters required for ultrasonic disintegration were determined. The results of evaluating the effectiveness of the application of the developed technology are presented. The results obtained confirm the effectiveness of the developed technology and make it possible to proceed to the creation of a new methodological approach for laboratory diagnostics. The potential area of ​​application of the developed technology is diagnostic laboratories and blood storage and transfusion centers.

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