To investigate Thyroid function abnormalities in individuals with chronic renal disease

Abstract

During our research, 50 CKD patients on conservative treatment were examined for thyroid function issues at the Department of Medicine at the Medical College and Hospital in China. The participants' ages range from 20 to 68. There were 34 men and 16 women among the patients, a ratio of 68% to 32%. The average duration of CKD symptoms is 9.84 months, although they can last anywhere from 4 months to 30 months. Between 6 and 32 ml/min, creatinine clearance occurs. The range of urea levels in the blood was 45-184mg/dl, with a mean of 102.12mg/dl. The range of serum creatinine concentrations was 3-14mg/dl, with a mean of 7.34mg/dl. In 10 patients, the serum calcium level was low; in 28 patients, it was normal; and in 12 patients, it was high. Twelve individuals had low serum phosphorous levels, whereas the 38 others were within the usual range. For example, serum T3 was measured between 0.2 and 2.0ng/ml, the average was 0, serum T4 was measured between 0.09 and 8.4g/dl, the average was 5.65, and serum TSH was measured between 0.06 and 38IU/ml, the average was 6.49 (normal range is 0.04 to 7.49 IU/ml). There were 29 individuals with low T3, 12 with low T4, and 4 with hypothyroidism in our research. 34 out of the 68 individuals had hypothyroidism-related symptoms. In our research, as people get older, the likelihood of developing Low T3 syndrome increases as well. As the severity of chronic renal disease grows, so does the number of individuals who have low T3. Renal failure severity is not related to the number of people with low T4 syndrome. It has been discovered that the serum T3 level is lower in those with poor GFR. The mean TSH levels in all phases of renal illness in individuals with low T3 syndrome are all within the normal range, and there was no connection between TSH levels and glomerular filtration rate (GFR). CKD patients' low T3 levels might be considered protective since they promote protein conservation.