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Psoralea corylifolia (Family: Fabaceae) seeds, commonly known as Psoralea or Babchi seeds. Seeds are used as therapy for various skin problems and they also produce pigment for skin disorders as leukoderma and vitiligo. It is also having anti-bacterial, anti-fungal, anti-oxidant, anti-cancer, anti-larvicidal, anti-diabetic, and anti-inflammatory properties. The present study was to evaluate the preliminary Phytochemicals and the inhibitory activity of the cyclooxygenase and the lipoxygenase enzymes. The cyclooxygenases and lipoxygenase enzymes inhibitory activities were evaluated to determine the promising mechanism of the anti-inflammatory activity of Psoralea corylifolia seed. This study has revealed the presence of phytochemicals as Carbohydrates, Alkaloids, Phytosterols. Oils, Saponins, Proteins, Amino acids and Flavonoids.