Evaluation Of Analgesic and Anti-Inflammatory Activities of Ethanolic Extract of Sida Cordata In Animal Model

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Srinivasan K, Manickavalli E, HajaSherief S, Sivakumar T

Abstract

Inflammation is a widespread condition that is elicited by the body as a defensive reaction to pain signals. Fortunately, chronic inflammation can contribute to a plethora of illnesses, especially cancer. In folk medicine, Sida cordata L. (Malvaceae) is used to manage blennorrhea, asthmatic bronchitis, and nasal discomfort. Therefore, the anti-inflammatory, analgesic, and antioxidant activities of ethanolic extract of Sida cordata (EESC) were evaluated in animal models by different methods. The hot plate and acetic acid tests were used to evaluate the analgesic activity whereas, carrageen, serotonin, and histamine-induced paw edema and cotton pellet-induced granuloma formation were used to study the anti-inflammatory activity of Sida cordata. The administration with 100 and 200 mg/kg of EESC reduced the pain and inflammation indicating that it possesses analgesic and anti-inflammatory activities. The significant anti-inflammatory activity in a dose-dependent manner and the percentage of inhibition at both the doses after 30 min and 6 h was 32.98%, 67.61% and 38.91%, 68.82% respectively, whereas the EESC with a maximum inhibition of 66.94% for serotonin and 53.66% for histamine at the doses of 200 mg/kg. However, in Cotton pellets induced granuloma formation, the EESC at both the doses showed a significant weight reduction, as 43.76% and 51.06%, respectively, and the standard drug showed 55.33% weight reduction of dried cotton pellets. Hence, our study indicates that Sida cordata possesses analgesics and anti-inflammatory, activities and it may be useful as an anti-inflammatory agent in inflammation-associated disorders.

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