The Disadvantages Of Curcumin Based On Its Phytochemical Composition And Anti-Inflammatory Activity In Peripheral Nerve Regeneration In Sciatic Nerve Injury

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Ria Margiana , Kamila Alawiyah , Khoirul Ima, Rizni Fitriana , Arif Rahmat Widodo , Theresa Devi Siswani Tjandra Wibowo , Susanti Pakaya


BACKGROUND: Illnesses related to the somatosensory system, lesion, or even sciatic nerve injury result in the emergence of neuropathic-related pain, a fact that calls for the need of carrying out a peripheral nerve regeneration, especially in curing the resultant pain due to the sciatic nerve injury. This form of injury relates to peripheral neuropathic pain, and therefore, it comprises of the rapture of or the damage to the peripheral nervous system. It is worth acknowledging that approximately 10-15% of people experience an acute form of postoperative pain and subsequent constant pains after taking surgery procedures. Such instances often call for the application of anticonvulsants, clonidine, baclofen, and antidepressants as treatment remedies and approaches of thwarting and ending peripheral neuropathy, as opioids apply in the treatment of postoperative pain.

AIM: This study aimed to discuss the disadvantages of using Curcumin as treatment mitigation in peripheral nerve regeneration in sciatic nerve injury based on its anti-inflammatory activity and phytochemical composition.

METHODS: The study that used in this method was quantitative research.

RESULTS: The application of these drugs, however, presents some negative effects. As such, there is the necessity of soliciting better therapeutics as alternatives, especially those that have limited to no side effects and improved efficacy. This consideration presents the need to implement the use of Curcumin. As a polyphenol generated from the Curcuma longa roots, Curcumin has anti-inflammatory, antioxidant, and antibacterial medical properties. Additionally, the adoption of Curcumin presents a faster rate of metabolism and reduced bioavailability; both of them have resulted in the establishment of different formulations of Curcumin. The need to implement Curcumin and its associated formulations as medical remedies to postoperative and neuropathic pains elevate the significance of comprehensive analysesof its effects regarding their reliability to perfect execution of such health functions. As per the positive results obtained from both clinical and preclinical pieces of research, Curcumin reflects a quite considerate degree of reliability as a mitigation or health remedy appropriate in the prevention of postoperative and neuropathic pain conditions. Therefore, the disadvantages associated with the use of Curcumin in the peripheral regeneration of nerve in sciatic nerve injuries avails the need to improve its formulations so that its health side effects as post-operative and neuropathic drugs can be lowered as far as possible for their reliable and effective medical application.

CONCLUSION: The case for peripheral nerve injury patients was not 100% reliable curcumin as a remedy, but it makessome assumptionsof some disadvantages during its administration unto the patients.It is necessary to establish a curcumin formulation with minimal to no post-surgery pains and aftermath of Curcumin-related health complications.

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