Assessment Of In Vitro Antioxidant And Xanthine Oxidase Inhibitory Potentials Of Ethanolic Stem Extract Of Cissus Quadrangularis

Abstract

Aim: The present study was aimed to evaluate the in vitro antioxidant and xanthine oxidase inhibitory potentials of ethanolic stem extract of Cissus quadrangularis.L.

Background: Cissus quadrangularis is the commonest species, belonging to the Vitaceae, commonly referred to as “Hadjod'', a perennial plant. The stem of the Cissus quadrangularis was used to treat many diseases like piles, pain in joints, swelling out, scurry,  asthma, disease of ear and nose bleeding. Xanthine oxidase is an enzyme catalysing the conversion of hypoxanthine to xanthine and xanthine to uric acid which get excreted by kidneys. Excessive production or inadequate excretion of uric acid results in hyperuricemia and gout.

Materials and methods: Ethanolic extract of Cissus quadrangularis were tested for its phytochemical constituents, in vitro antioxidant, xanthine oxidase  inhibitory potential using standard protocols.Data were analysed by ANOVA and DUNCAN’S multiple range test to check the statically significance among the groups. The results with the p<0.05 level were considered to be statistically significant.

Results: The results indicate the rich existence of phytochemicals in the ethanolic stem extract of Cissus quadrangularis. The extract also showed potent antioxidant and xanthine oxidase inhibitory potential in a concentration dependent manner.

Conclusion: The study showed the potent in vitro antioxidant and antigout activity of Cissus quadrangularis. The presence of phytochemicals might have contributed to the beneficial properties of the extract.