Comparison Of the Effectiveness of The Three Types of Absorbable Collagen Membrane In The Reconstruction Of Rabbit Skull Bony Lesions In The Histologic And Histomorphometric Method

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Mohammad Tavakoli , Nasrin Dibaji , Zahra Sajedi , Jaber Yaghini , Ahmad Mogharehabed , Ardeshir Talebi

Abstract

Introduction: The use of the barrier membranes is a standard method for the regeneration of bone lesions related periodontal diseases as well as pre - and post - implant treatments. Despite the research carried out in this regard, a complete study in Iran has yet to study the comparative study of commercial types of this membrane (absorbable), and further studies are needed. Therefore, this research is done on the histological and histomorphologic examination of this membrane and its comparison with the foreign brand on the rabbit skull.


Materials and methods: In this experimental animal study, 24 New Zealand male rabbits were used with weight of 2 kg and 20 weeks old. The specimens were divided into four groups (Tehran, Biomend, Senomembrane (Kish) and control). In all specimens, two defects with a diameter of 11 mm were created in the skull and randomly treated with three types of membrane. After sacrificing rabbits at 3 weeks and 10 weeks, the amount of bone formation and membrane remnant was assessed histomorphometrically and inflammation rate by histologic method. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests with 95% confidence interval was used to compare the data (P<0.05).


Results: The results of this study showed that in all groups, the average percentage of bone formation was incremental. However, this difference was significant only in Senomembrane group (PV = 0.016). Compared to two periods of time, the average percentage of membrane remnant in all three groups of Tehran (PV= 0.002), Senomembrane (PV = 0.002) and Biomend (PV = 0.003) decreased significantly in week 10 compared to week 3. Degree of inflammation was significantly decreased in all three groups of Tehran (PV = 0.005), Senomembrane (PV = 0.002) and Biomend (PV = 0.002) over time.


Conclusion: In this study, the effectiveness of Biomend membrane was shown in the short term in comparison with the membrane of Tehran and Senomembrane in relation to bone formation. However, after 10 weeks, the results of regeneration of Iranian membranes were close to the foreign brand.


 

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