Evaluation of effect of platelet rich fibrin (PRF) and Demineralised Freeze-dried bone allograft (DFDBA) in maintaining dimensional changes of Transalveolar extraction socket

Abstract

Aim: Comparison of dimensional changes in non-augmented transalveolar extraction sockets with those augmented with Platelet-rich fibrin (PRF) and Demineralized Freeze-Dried Bone Allograft (DFDBA).

Methodology: The study included 30 patients between 18 to 50 years who are scheduled to undergo transalveolar extractions of the mandibular third molar. Patients were randomly divided into three groups. In group, A extraction sockets will be left for routine healing while in group B augmented with PRF while in group C, augmentation was done with DFDBA. All the patients were observed for 6 months after the surgery. Clinical Parameters (Pain and soft tissue healing) were taken at baseline, 1 week and 6-month intervals while Radiological parameters like .mesiodistal width and cervico-apical height were compared with CBCT image help at baseline and 6 months.

Result: The matching groups were matched based on Age, Gender and Tooth number. There was a non-significant difference in pain scale and soft tissue healing between the groups at all time intervals. The mean vertical height of bone was comparable at baseline but showed a significant difference in group A (7.59±0.74 mm) as a comparison to group B (10.95±0.66 mm) and group C(10.53 ± 0.75 mm) at 6 months. A similar result was also obtained with mean mesio-distal width, which also showed a significant difference in group A (8.62 ± 1.60 mm) as a comparison to group B (9.77 ± 1.10 mm) and group C (9.95 ± 0.98 mm) at 6 months. 

Conclusion: The present study indicates a significant improvement in the regeneration of bone after third molar surgery in cases treated with PRF and DFDBA. The use of autologous PRF and DFDBA in the healing sockets (extraction sites) and surgical sites is recommended to improve bone healing and minimize resorption