Assessment of Malondialdehyde, and Some Inflammation Parameters in Iraqi Osteoporosis Women

Abstract

  Osteoporosis is chronic degenerative disease characterized by a decreased bon mass occurs when the balance between bone resorption and bone formation is lost. Recently   , oxidative stress malondialdehyde (MDA) , and some inflammation parameters like  C-reactive proteins (CRP), IL-1, IL6 and TNF-α   are believed to play important role in osteoporosis disease. Fifty osteoporosis women   patients were recruited into the study according to the presence of MDA ; as compared with forth healthy controls the age range was between (42-60) years. Hs-crp, IL-6, TNF-α and MDA determination by ELISA KIT , Biosorce ,USA. In present study   showed significantly increase in   MDA   levels (mean ±SD)  in osteoporosis women compared with control ( 27.01 ± 5.66) vs (12.01 ± 2.04) , p value = 0.01 , and also  significantly increase in  IL1β levels (mean ±SD) in osteoporosis women compared with control  ( 7.44 ± 3.86) vs(  2.11 ± 2.74 ), , p value = 0.01 and TNF-α also significantly increase  p value =0.01, while there were significantly decrease in vitamin D3 levels p value =0.01. The study concludes that levels of malondialdehyde and Vit D may help diagnose women with osteoporosis and bone loss.