Study the Interferon –γ , C- reactive Protein and Lipid Profile in Iraqi Diabetic Patients With and Without Hypertension

Abstract

Diabetes mellitus is a major challenge for global public health, and it characterized by elevated glucose. The current study aimed to research association between serum lipid profile and cytokines in type 2 diabetes mellitus patients with hypertension  and  without  hypertension. The study population comprised of (80) type 2 diabetes mellitus patients patients' (38 without hypertension and 42 with hypertension) having age group (36-59) year and ( 40 ) number of healthy subject having age group ( 30-50 ) year, has been done at National Diabetes Center / Mustansiriyah University in Baghdad, Iraq.  The results showed a significant increased ( P<0.05) of FBG and HbA1c values in male and female patients with type 2 diabetes mellitus patients for both groups ( with hypertension and without hypertension) compared to control group. While, HOMA-B% and HOMA-S% which significant decreased ( P<0.05) in male and female patients with type 2 DM for both groups ( with hypertension and without hypertension) compared to control group. The values of lipid profile ( total cholesterol, triglyceride ,  low  density lipoprotein and very low density lipoprotein) which significant increased( P<0.05) in male and female patients with type 2 diabetes mellitus for both groups ( with hypertension and without hypertension) compared to control group. While  high density lipoprotein  value was significant decreased in male and female  patients. Also significant increased( P<0.05) in CRP level in male and female patients with type 2 diabetes mellitus for both groups ( with hypertension and without hypertension) compared to control group. While  IFN level was significant decreased in male  and female patients with type 2 diabetes mellitus for both groups ( with hypertension and without hypertension) compared to control group . In conclusion, this study demonstrated that type 2 diabetes mellitus patients have disorder levels of  Interferon –γ and C- reactive Protein may lead to several diseases also,  increased level of glycocelated hemoglobin levels point toward poor control of blood glucose levels, dyslipidemia is obvious in patients with type 2 diabetes which may lead to several diseases.