The impact of ZnO Nanoparticles on the liver and lung tissues in mice

Abstract

According to the distinctive physical and chemical properties, nanoparticles were used in several care products, cosmetics, sunscreens, drug delivery systems, and for therapeutic purposes, among the most common nanotechnology in consumer and medical products are (ZnO NPS), so aimed the present study to investigate an inflammatory impact of ZnO NPs on the mice's liver and lung. Materials and methods: it used twelve male mice of Mus musculus, injected (i.p) a treated group with ZnO NPS (400 mg/kg) for 20 days, as for the control was injected with 0.5 ml of physiological solution 20 days. Results: ZNO NPS caused infiltration of inflammatory cells in different areas of both liver and lung tissues, significantly increased mmp12 gene expression in both the tissue of liver and lung. From these results, we can conclude that the zinc oxide nanoparticles caused a histopathological change in the liver and lung thus its inflammatory effect is obvious tissue through the infiltration of inflammatory cells.