Clinical and Biochemical profile of polycystic ovarian syndrome among adult women of Reproductive age (20-45 years)

Abstract

This study was designed to provide an overview of the clinical and biochemical profile of the adult women with polycystic ovarian syndrome. A total of 102 adult women in the age group of 20-45 years with PCOS was selected for the present study. Rotterdam criteria was used for identification of the subjects for the study and considered for the further study. Socio economic status of the selected subject revealed that majority(60 %)  of the subjects belonged to lower middle class . Hyperandrogenism is one of the major symptoms observed in young adult women with PCOS. Hirsutism (67%), clinical features of hyperandrogenism such as Acne, Androgenic Alopecia Acanthosis were present in more than 50 % of the selected subjects.Thirty five percent had increased testosterone level  and 84 % showed the positive radiological evidence of PCOS. Biochemical profile of the selected subjects revealed that there was a significant difference in HDL (p=0.004), TG(p=0.008), Hb (p=0.016) and WC(p=0.015) compared to the standard values and also there was a significant high positive correlation between body fat percentage,  BMI  and WHR. Among the selected subjects with PCOS who had metabolic syndrome, 69.3 percent were correctly predicted based on the regression model. Those PCOS subjects having high WHR, menstrual irregularity showed 3.1 times and 3.6 times higher risk for developing metabolic syndrome respectively. Abdominal obesity and certain metabolic disturbances became major concerns for older women with PCOS.Clinical and Biochemical profile of polycystic ovarian syndrome among adult women of Reproductive age is an important aspect to be considered for promoting  the health status holistically.