Effects Of New Derivatives Of 1, 2, 3 – Triazoles On Liver Glycogene And Some Biochemical Indicators In The Blood Of Alloxan-Induced Diabetic Rats

Abstract

Impacts of heterocyclic compounds - new derivatives of  1, 2, 3 – triazoles to the amount of glycogen in the liver homogenate, the amount of glucose in the blood plasma,  activity of aspartate aminotransferase (Al AT) and alanine aminotransferase (As AT) of the healthy and alloxan-induced diabetic rat were studied in vivo experiments. New derivatives of 1, 2, 3 - triazoles were administered to diabetes-induced animals once daily for 10 days through the per os method. It was determined that the amount of glycogen in their liver was almost close to the control (intact) level after pharmacotherapy of diabetes-induced rats with new derivatives of 1,2,3-triazoles. New derivatives of 1,2,3-triazoles were found to be able to restore AsAT and AlAT activity, which play a key role in carbohydrate metabolism in animal liver homogenates in the diabetes-induced model.