The Association Of ACP5 Gene (Rs2071484) Polymorphism With Osteoporosis In Patients Of Babylon Province/Iraq

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Shaimaa Hussein Ali , Prof . Dr. Hussein Jasim ObaidAl-Harbi , Prof.Dr.Ali Mohammad husseinalqazzaz

Abstract

The aim of the study was to evaluate the association of ACP5 gene polymorphism rs2071484 with osteoporosis patients.This studyinclude 150 (20 men and 80 women)osteoporosis patients and 50 (19 men and 31 women) healthy as control group.Genotyping of rs2071484 of ACP5gene was carried out using the polymerase chain reaction-basedSingle strand conformation polymorphism (SSCP)technique.The result of this studyshowed ACP-5(rs2071484) was associated with osteoporosis in Iraqi patients and CC genotypes were high associated with osteoporosis disease by OR=4.47. In Conclusion: The ACP5rs2071484 polymorphism was associated with osteoporosis in Iraqi patients and CC genotypes were high associated with osteoporosis disease.

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