Using The Aqueous Extract Of Allium Sativum In Improvement Of Some Physiological And Immunological Parameter In Albino Rats

Abstract

The current study was  designated to investigate the effect ofAllium sativumon some physiological and immunological  parameters  in rats. thirty adult rats  were divided into three groups (10 rat for each). G1: served as healthy control, G2 :rats were treated with 150 mg\kg of Allium sativum, G3: treated with 300 mg\kg of Allium sativum.  All treated animals were givenorally for 30 days. The effects  of garlic on some  parameters were investigated such asalanine transaminase (ALT), aspartate transaminase(AST), lactate dehydrogenase ( LDH), total and differential counts of white blood cells(WBC) like Lymphocyte, Monocyte, Neutrophil, Basophil, Eosinophil,as well as the level of Malondialdehyde (MDA),C-reactive protein (CRP), catalase (CAT), glutathione (GSH) and tumor necrosis factor alpha (TNF-α)  , the results administrated a significant decreased in the ALT and AST level in  group treated with  150 and 300 mg\ kg of Allium sativum as compared with control  also the results displayno significant in LDH level in treated groups with150 and 300 mg\kg of Allium sativum. The values of WBC show high significant increased in all groups treated with 150 and 300 mg\kg of Allium  compared with control while the results obtained significant  decreased in neutrophil in all groups that treated with  150 and 300  compared with control, also the results investigated  a significant decreased in serum level of  MDA, CRP,CAT, TNF-α  while the level of CAT relieved  significant increased in group treated with  150 and 300of aqueous extract of Allium sativum.