The Bioactive Effect Of Royal Jelly Against Histamine Level Induced By Lysophosphatidic Acid (Lpa)

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Hoda M Elsayed

Abstract

Royal jelly (RJ) is a natural food that widely used to boost medical therapy for a variety of illnesses and improve physiological activity as well as enhance the body's natural immunological response. Histamine is one of the acute inflammatory and hypersensitivity reactions mediators which involved in the regulation of allergic responses and control multiple key processes in the immune response. The current study aimed to evaluate the inhibitory activity of RJ on histamine releasedfrom activated RBL-2H3 cells by lysophosphatidic acid (LPA). Royal jelly was administered to RBL-2H3 cells lines treated with LPA, and histamine expressed levels were determined using a spectrofluorometric technique. Royal jelly significantly reducedthe level of histamine produced in a time- and a dose-dependent manner (p < 0.001).Moreover, RJ had no significant cytotoxicity on RBL-2H3 cells.Our data suggested that RJ is an anti-allergic natural product that aids in the reduction and attenuation of allergic reactions. These effects might be connected to its ability to improve allergic symptoms by reducing histamine level.

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