Comparison On Anti-Hyperglycemic Activity Of Sambilotoleaves (Andrographis Paniculata (Burm. F.) Nees) And Turmeric Rhizome (Curcuma Domestica Val) Ethanol Extracts In White Male Mice

Abstract

Sambiloto (King of Bitters) and turmeric are empirically used by Indonesiansfor antidiabetic Mellitus. Therefore,thisstudyaims to examine the anti-hyperglycemic activity fromvarious doses of Sambilotoleaves and turmeric rhizome on white male mice. The studyusedan antihyperglycemic activity test with alloxan induction administered intraperitoneally (IP). Furthermore, 35 mice were used and divided into 7 groups (n=5), namely, the comparison with glibenclamide (0.013 mg/20grBW), the control with Na-CMC, Dose 1 Sambiloto 100 (1.12 mg/20grBW), Dose II Sambiloto - Turmeric 75:25, Dose III Sambiloto - Turmeric 50:50, Dose IV Sambiloto - Turmeric 25:75,and Dosage V Turmeric 100 (1.4 mg / 20 g BW). The data wereanalyzed statistically using the Annova method with a 95% confidence level. Moreover,the results showed that all test groups in 1 to 5 doses (P values 0.001, 0.0061, 0.0004, 0.0029, 0.0348,and 0.0011) hadasignificant effect on reducing blood glucose levels in mice compared to the control (p-value < 0.005). Based ontheseresults, the Sambilotoethanol extract, turmeric, and the combination had activity in reducing blood glucose levels.