Protective Effect Of Rosmarinus Officinalis L. Against Hepatic Injury Stimulated By Ferric Chloride In Male Rats

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Amel Taha Yaseen , Mafaz Khalid Saeed , Razan Y.Q. Al-Abachi , Alaa Younis Mahdy Al-Hamadany , Shihab A. Al-Bajari

Abstract

Rosmarinus officialis L., Lamiaceae, has been used in Iraq for decades to cure a variety of diseases and is considered as a desirable species owing to its medicinal benefits and bioactivity. The purpose of this research was to find out more about that the Rosmarinus officialis L plant might significantly reduce the harmful effects of ferric chloride. Fifty male rats were divided into five main groups: control (no additions), FeCl3 group, and the remainder of the groups were fed Rosmarinus officialis L. components (flavonoid, glycoside, and alkaloids) to monitor the affected liver function. FeCl3 raised aspartate transaminase, alanine transaminase, gamma-glutamyltransferase, and alkaline phosphatase levels, while Rosmarinus officialis compounds reduced FeCl3 toxicity. In contrast to the FeCl3 group and FeCl3 groups containing Rosmarinus officialis L. plant components, there was a significant difference (P<0.05) in total lipid profile, total protein, albumin, and globulin levels in the control group. In compared to the control group, lipid peroxidation resulted in a significant amount of malondialdehyde in the FeCl3 group; however, Rosmarinus officialis components lowered the level of FeCl3, reducing oxidative damage. In compared to those fed just FeCl3, the levels of glutathione, catalase, and glutathione peroxidase rose in the groups fed Rosmarinus officialis components. The levels of superoxide dismutase had significantly slightly differences amongst the groups that were examined.

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