Association Between Some Candidate Gene Variants And The Development Of Osteoporosis

Abstract

Osteoporosis is a polygenic condition that has been linked to more than 30 candidate genes, the majority of which are also involved in bone mineral density regulation (BMD). Because the receptor of vitamin D (VDR) governs Vit-D action, VDR gene polymorphisms may be linked to a variety of disorders. The COL1A2 (collagen type I alpha 2) gene encodes collagen type I, which is a component of the bone matrix and may be a risk factor for osteoporotic fracture. There were no significant variations in ApaI genotype (rs7975232) frequencies between the patients and controls, according to the current findings. heterozygous C/A with homozygous C/C (OR=0.1365, 95 percent CI=0.0072 - 2.5895, P= 0.1847), and the homozygous variation A/A genotypic frequency compared to homozygous C/C (OR=0. 1127, 95 percent CI= 0.0060 - 2.1070, P= 0.1440). In the VDR ApaI (rs7975232) polymorphism, a difference in significancy appears in allele Afrequenciesofpatients compared to groups of control (OR= 0.9252, 95 percent CI =0.4556 - 1.8784, P=0.8295). Between the patients and controls, there were no significant variations in BsmI genotype (rs15444410) frequencies. heterozygous A/G vs. homozygous G/G genotypic frequency (OR=0.3652, 95 percent CI=0.0402 - 3.3174, P= 0.3709) and the homozygous variation A/genotypic A's frequency compared to homozygous G (OR=0.2833, G's 95 percent CI= 0.0293 - 2.7444, P= 0.2763). In the CAT C-262T polymorphism, difference in significancy appears infrequency of A allele between control and patients’ groups (OR= 0.7463, 95 percent CI = 0.4075 - 1.3669, P=0.3433). Between the patients and controls, there were substantial variations in COL1A2 genotype (rs412777) frequencies. heterozygous A/C vs. homozygous A/A genotypic frequency (OR=0.2298, 95 percent CI= 0.0613 -0.8614, P= 0. 0292), and the homozygous variation C/C genotypic frequency compared to homozygous A/A (OR=0.9375, 95 percent CI=0.1326 -6.6285, P= 0.9484). In the COL1A2 gene (rs412777) polymorphism, there were no significant changes in C allele frequencies between patients and controls (OR= 0.8759, 95 percent CI =0.4911 -1.5621, P=0.6536).