New Functional Biologically Active Polymers Based On N-Substituted Maleimides

Main Article Content

Ammar Abdul-Hussein Awad and Mohanad Mousa Kareem

Abstract

New homogenous and heterogeneous polymers have been derived from two maleimide monomer through imidization of m-aminobenzoic acid with maleic anhydride in glacial acetic acid. The resulting 3-maleimide benzoic acid was converted to acid chloride derivative and condensed with two amino drugs (Paracetamol and Metoclopramide) respectively, in presence of triethyl amine as catalyst afforded two new maleimide-drug monomers (A1and A2). Homo-polymers (H1and H2) and Hetero-polymers (H3 and H4) were synthesized via polymerization of each of A1 and A2 with equal amount of acrylic acid, benzoylperoxid (Bpo) used as an initiator under nitrogen atmosphere. All prepared compounds were characterized by FT– IR and 1H NMR, and screened for their antibacterial activity against pathogenic strains of E.coli (ATCC 8739) and S. aurous (ATCC25923) at concentration of 0.5 mg/mL using corresponding drugs as standards by disk-diffusion method. The results show increase in the antibacterial activity for monomers and polymers comparison to the Paracetamol and metoclopramide drugs control. The drug release and swilling ratios of prepared polymers were investigated.

Article Details

Section
Articles