Design, Synthesis, And Antimicrobial Evaluation Of Some Glycine-Barbiturate-1,2,3-Triazole Hybrids

Abstract

Synthesis new glycine-barbiturate derivatives as probable antibacterialand antifungal agents was prepared, and identified by some analytical techniques such as FTIR, and NMRspectroscopy. The targetglycine-barbiturate-1,2,3-triazole compounds were testedin vitro against two types of bacterial strains (Bacillus subtilis, Staphylococcus epidermidis, Escherichia coliand Pseudomonas aeruginosa) and two fungal strains (Aspergillus niger and Candida albicans). The obtainedresults of biological activities exhibited that some of the evaluatedglycine derivatives showed higher activities than the control drugs.