A Study Of Thyroid Peroxidase And Creatine Kinase With Thyroid Patients

Abstract

Thyroid gland is the most common endocrine glands, and thyroid dysfunction isThe most common problem of endocrine system. Thyroid disorder can be divided in two main group hypothyroidism and hyperthyroidism. In hypothyroidism the level of TSH (thyroid stimulate hormone) becomes higher than control, while T3 (triiodothyronine), T4 (thyroxine) decrease than the control group .In hyperthyroidism the level of TSH (thyroid stimulate hormone) becomes lower than control, while T3 (triiodothyronine) T4 (thyroxine) increase than the control group.
In this study, creatine kinase (ck-mb) was used as a new marker to confirm its relationship with thyroid dysfunction.
The aim of this study is to find the distribution of Creatine Kinase ,Thyroid peroxidase ,lipid profile (HDL (high density lipoprotein),LDL(low density lipoprotein), Cholesterol ,T.G (triglycerides),VLDL (very low density lipoprotein) in three group hypothyroidism ,hyperthyroidism ,healthy people and the relationship between them with other parameters (gender and age ) in some Iraqi patients.
This study had concluded (105) patients diagnosed by specialist, (35) patients Hypothyroidism, (35) hyperthyroidism, (35) healthy subjects as control group. The age range between (16-55) year’s .The samples were examined and diagnosed at The National Diabetic Center /AlMustansuriya University in Baghdad /Iraq From the period (Dec. 2020 to Apr. 2021).
The distribution of hypothyroidism in was significantly higher in female (88.57%) than males and in hyperthyroidism also female was higher with (68.57%).The results of age and BMI found that the higher rate of hypothyroidism in age (37.97+_2.35) and in hyperthyroidism in age (40.83+_1.98).
The thyroid function tests were used in this study, including T4 (Thyroxine), T3 (Triiodothyronine), TSH (Thyroid stimulating hormone).There is no significant difference between T3and thyroid disorders with (1.441+_0.12b) in hypothyroidism and (3.232+_0.27b), while T4, TSH, TPO were highly significant. In hypothyroidism patient T4was (81.68+_7.07b) while TSH was (26.25+_4.70a) and TPO was (10.14+_0.17b). And in hyperthyroidism patients T4was (155.95+_10.47a) while TSH was (0.164+_10.47a) and TPO was (10.73+_0.34b).
The activity of CK (creatine kinase) was found to be elevated in the samples of hypothyroidism contrast to control group with values (2.305+_ 0.17) and (1.834+_0.15) respectively.
While the Ck (creatine kinase) activity in hyperthyroidism showed values (2.386+_0.18).
The lipid profile biomarkers was determined of both patients groups and compared with control group .the results of that showed cholesterol was elevated in hypo and hyperthyroidism contrast with control group with values (169.74+_5.19),(150.17+_5.72),(115.93+_3.90) respectively while the values of Triglycerides was showed this values
hypo(140.08+_5.19),hyper(134.91+_11.80),control(90.32+_4.20).
The very low density lipoprotein levels were remains within normal values for the three groups.The HDL (high density lipoprotein) values showed non-significant results in both groups compared with control group.The LDL (low density lipoprotein) was found to be higher in all groups with values hypo (102.48+_4.63), hyper (94.25+_5.47), control (119.47+_5.27)