Preparation With Studying Biological Activity For New 1,2,3-Triazole Derivatives Of Sulfamethoxazole

Abstract

A serious 1,2,3-triazole derivatives were prepared by reaction between4-azido-N-(5-methylisoxazol-3-yl)benzene sulfonamide with different triple bond derivatives in presence CuCl and sodium ascorbate as catalyst. FTIR, and NMR have established the chemical structures of the target compounds. All end derivatives were evaluated to in vitro antifungal testing against two types of fungi (Aspergillus niger and Candida albicans) and antibacterial screening against four pathogenic strains (Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus epidermidis, Escherichia coli). The findings indicate that the compounds being tested displayed promising activity and warranted further consideration as potential anti-micro bales.