Assessment of plasma cytokine and complete blood count parameters in nitroglycerin migraine model

Abstract

Migraine, characterized by headaches, is very common and that may be associated with immunogenic and neurogenic inflammation. Cytokines involved in neurogenic switching in migraine are TNF-α and IL10. The immune cells in peripheral blood play roles in peripheral inflammatory responses. Increased levels of peripheral inflammation may occur in patients with migraine and may be involved in the pathogenesis of migraine. In this study, 12 rats divided into two groups. The first six groups were normal rats and the last were rats that inoculated with nitroglycerin. Complete blood count (CBC) was compared between these two groups. SPSS was used for statistical analysis. There was positive correlation between TNF-α and IL10 with leukosit, platelet, hematokrit, eritrosit, neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio counts. The results of TNF-α and IL10 in migraine group were higher than control group significantly. In our study, we found that TNF-α and IL10 was higher in migraine than control group. TNF-α, IL10, leukosit, limfosit and neutrophils and lymphocytes ratio can be used as an inflammatory marker for migraine.