Assessment Of Matrix Metalloproteinase- 2 &Tissue Inhibitor -1 In Human Prostate Cancer

Abstract

Matrix metalloproteinases (MMPs) are a group of zinc -dependent enzymes that have a role in the tumor cell invasion and metastasis, so involved in different malignancies ,MMPs are essential in the degradation process and also promote cellular migration, regulate growth factors and cytokines, influence apoptosis and collaborate in neovascularization , the expression of these proteins is regulated by their physiological inhibitors :tissue inhibitors of metalloprotein (TIMPs) ,the expression levels of these proteins in tumoral, stromal, and inflammatory cells can be considered potential tumoral microenvironment invasion markers. The expression level of MMP2 and TIMP1 in serum wasdetermined by Eliza ,and in tissues by Immunohistochemistry. The present studyrevealed that MMP2&Timp1 levels were significantly higher in prostate cancer serum and tissue compared to controls, and their levels were positive associated with Gleason grades and stages in patients.