Molecular Genetic Analysis- Invivo Model Of Annonareticulata Leaves Against Den Induced Hepatocellular Carcinoma

Abstract

Cytochrome P450 2E1 (CYP2E1) plays an important role in both alcohol-induced and immune-mediated liver injury. However, the mechanism underlying CYP2E1 transcriptional regulation has not been clarified. In the present study, the immune gene expression profile was determined in rat liver samples and surrounding tissues by the synthesis of mRNA and cDNA synthesis. The gene and protein expression profile of CYP2E1 in response to treatment with AqAr and AgNPs-AqAr in the liver of experimental rats are discussed. However, the specific changes to CYP2E1 following immune-mediated and alcohol-induced liver injuries, the role and underlying mechanism of CYP2E1, and whether the injury process can be influenced by the selective regulation of CYP2E1 or CYP2E1-dependent oxidative stress have not yet been determined (1).