5 Fluorouracil Solid Lipid Nanoparticles (SLNs), Formulation and Evaluation for the treatment of Skin Disorders

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Rajesh Dodia, Dr. Mrunal K. Shirsat

Abstract

The new generation submicron is SLNs (solid lipid nanoparticles). In which the lipid particles are in liquid lipid and solid lipid. These are safe, very much stable and it is biodegradable. These may have various topical applications and has an ability to deposit on skin. For the release of drugs, these reduce the local side effect and provide sustained release effect of drug. The current work is done for the formulation and evaluation of SLNs for the treatment of skin disorder. 5 Fluorouracil loaded SLNs are formed and were characterised by FTIR, DSC studies. Physiochemical and In-vitro study also investigated. The entrapment efficiency is range from 60±0.36% to 78±0.36%. Zeta potential ranges from-32±2.0 to -59±1.3. 5 Fluorouracil loaded SLNs have prolong release. This is followed zero order in vitro release kinetic.

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