Some Aspects Of The Toxic Effect Of Karate Pyrethroide On Rat Liver Metabolism And Ways Of Their Correction

Main Article Content

Mirkhamidova P. , Tuychieva D. , Alimova R.

Abstract

The activity of alkaline phosphatase, a secretory enzyme synthesized in the liver, has been studied. The research results showed that the activity of alkaline phosphatase increases in comparison with the norm by 2-3 times. According to the accepted identification of clinical diagnostics, such activity is inherent in the liver, in which the parenchyma is inflamed or affected, as a result of which the membranes are also affected. This, in turn, leads to the release of organolytic enzymes into the blood. Apparently, in these experiments, pyrethroid karate destroys the membrane structures of cells, and those isomers of alkaline phosphatase that are contained in organelles do not leak into the blood. Therefore, it can be assumed that this is the reason for the invariably high activity, which is found on the 30th and 50th days of poisoning of karate rats. After the introduction of the antioxidant RAF to poisoned rats, the activity is gradually restored. On the 50th day, the activity of alkaline phosphatase is restored.

Article Details

Section
Articles