Serum Myeloperoxidase Activity Association With Cardiovascular And Kidney Disease Risk Factors In Pre-Diabetic And Type 2 Diabetic Patients

Abstract

Type 2 diabetes mellitus (T2DM) is one of the most common kinds of diabetes. Insulin resistance and insulin insufficiency are the causes. Myeloperoxidase (MPO) is a pro-oxidant enzyme produced by activated neutrophils, monocytes, and some tissue macrophages in their granules. While one of MPO's main biological functions is to protect the body from infections by producing antimicrobial oxidants, free radicals, and other reactive oxidant species, this activity can also cause endothelial and vascular oxidative damage.Materials and Methods: By using an ELISA kit, serum levels of human myeloperoxidase was measured in 30 patients type2 diabetic ,30 patients Prediabetic and 30 subjects as control group. The age range (30-65) years. Fasting blood sugar (FBS), HbA1c, CRP and Lipid profile by enzymatic method. Also, body mass index (BMI) measured .Blood samples were talked after fasting. Results: The serum MPO levels were significantly higher in Type2 diabetes Mean ±SD (13.10±3.4) and significantly increased MPO was prediabetic subjects Mean ±SD (9.57±2.80 ) as compared to controls. MPO was found to be significantly and positively correlated with all the cardiovascular disease risk factors i.e. age, gender ,body mass index (BMI), lipid parameters except high density lipoprotein (HDL) to which it was negatively correlated. The serum MPO levels were positively correlated with the albumin creatinine ratio (ACR), glycated hemoglobin (HbA1C) and FBG.Conclusions: Serum MPO levels were linked to ACR, HbA1c, LDL, and FBG in type 2 diabetic patients, suggesting that elevated levels in these patients could be used to measure vascular dysfunction. In pre-diabetes, MPO has a strong relationship with cardiovascular disease risk factors. As a result, MPO may be utilized to assess cardiovascular risk in pre-diabetic individuals.