Hypocholesterolemic Effects of Maysghurt as A Functional Food

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Fatmawati Nur , Hafsan, Muh. Khalifah Mustami ,Khaerani Kiramang, Aminah Hajah Thaha

Abstract

Hypercholesterolemia is known to have a strong correlation with cardiovascular disease cases. One alternative action that can reduce cholesterol levels in the blood is the provision of functional food. Not many studies have revealed the functional effects of maysghurt, a fermented drink made from sweet corn, to treat hypercholesterolemia. This experiment consisted of six treatment groups to determine the effect of hypercholesterolemia therapy with maysghurt on white male rats Rattus norvegicus Wistar strain in terms of serum and digesta total cholesterol levels, HDL, LDL and the ratio of LDL to HDL. This study used 46 male Rattus norvegicus. Rats models of hypercholesterolemia were obtained by giving Hyper cholesterol-inducing suspension (HIS) in the form of the beef brain that had been steamed and blended at a dose of 2 mL/day. The therapy of giving maysghurt was through gastric sonde technique with doses of 2 mL, 3 mL, 4 mL and 5 mL per 200 g of body weight of rats. The analysis used in this study is the One Way Analysis of Variance with Duncan's 5% further test. The results of the data analysis can be concluded that the gave maysghurt has a significant effect on reducing total blood cholesterol and digesta levels, and there is a positive correlation between serum and digesta cholesterol levels—the lower the serum cholesterol, the lower the digesta cholesterol of the rats. Maysghurt therapy reduced LDL levels and significantly increased HDL levels in hypercholesterolemic Wistar strain rats (Rattus norvegicus). This study also showed that maysghurt at a dose of 3 mL/200 g body weight of rats was the most effective in increasing HDL and lowering LDL in hypercholesterolemic rats. In general, this study reveals that maysghurt can reduce LDL levels, increase HDL levels, and improve the ratio of LDL to HDL so that it has the potential to reduce the risk of cardiovascular disease.

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