Research In The Field Of Development Of Technology Of Tablets "Sitmet"

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Ilkhamova Nargiza , Yunusova Kholida , Tashmatova Madina

Abstract

The article presents the results of the development of the composition and technology of "Sitmet" tablets. In the course of the study, methods were used to evaluate the technological properties of powders and tablets in accordance with the XIII State Pharmacopoeia. It is shown that the nature and quantity of excipients affect the technological properties (compressive strength and abrasion, disintegration) of Sitmet tablets. Technological factors are determined: the mixing time of the tablet mixture, the time of powdering the granulate. It is shown that the developed technology with the use of wet granulation ensures the production of tablets that meet the requirements for 36 months of storage in natural conditions.

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