Co-Processed Super disintegrant Loaded Atenolol Beads Sublingual Tablet for Hypertension

Abstract

Hypertension develops over many years and affects everyone eventually without having any signs and symptoms. It is considered as one of the primary medical issues and its successful treatment is of high significance. Last few years the remarkable advancement in the drug delivery system has been made. For this purpose current study focused on the formulation of atenolol sublingual tablet (ST) containing beads developed by co-processed superdisintegrants. Co-processed superdusintegrants were used to improvise the formulation and their processability and efficacy of the active drug. Atenolol is an antihypertensive drug combined with different superdisintegrants (croscarmellose sodium (CS), crospovidone (CP), and sodium starch glycolate (SSG)) at a different ratio to formulate beads, which again compressed into a tablet by direct compression technique. Formulated sublingual tablets were evaluated by different parameters for pre and post-compression studies. The post-compression parameters are weight variation test, hardness, thickness, friability, drug content, swelling index, pH, disintegration test, and in vitro dissolution studies at pH 6.8.  Compatibility study between drug-disintegrants was investigated by FTIR and DSC studies. Formulation F6 which contains a Co-processed superdusintegrant produces short wetting, disintegration, and dissolution time. Formulation F6 has shown faster drug release 100% at 4 min.