Synthesis of Benzothiazole Derivatives Using Green Biobased Vitamin B1 Supported on γ-Fe2O3@SiO2 Nanoparticles as Catalyst and Insilico Antiviral Activity Screening

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G Neelima, K Sesha Maheswaramma, K Bhaskar Reddy

Abstract

In the present research work, we report the synthesis of a series of benzothiazole derivatives synthesized and were docked for insilico studies against the influenza virus target. A novel biocompatible magnetic nanocatalyst was prepared by restraint of Vitamin B1 (Thiamine hydrochloride) supported on the surface of silica- encapsulated γ-Fe2O3 nanoparticles. Vitamin B1 was covalently associated with the silica to indulge a nontoxic, inexpensive and biodegradable for the formation of complex with γ-Fe2O3. Magnetic bio-nanocatalyst were characterized by FT-IR, XRD, TEM analysis. However, this catalyst can be simply detached from the reaction mixture by using a magnetic field and directly recycled for five times without loss of its significant activity. The synthesized derivatives were structurally characterized with FT-IR, 1H NMR and Mass spectra analysis. The antiviral activity and predicted insilico studies were prominent which revealed that compounds 3a and 3o illustrated better influenza virus inhibition as discriminated with the standard drug acyclovir. The efficacy of these synthesized benzothiazoles will need to be performing by in-vitro and in-vivo experiments as antiviral agents.

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