Screening Of Antioxidant Potentials Of Polyherbal Formulation In Experimental Animal Modules

Abstract

Poly herbal formulations, the name itself are indicating as multiple ingredients of different herbal origin. The plant ingredients may have wide spectrum of biological activities. Polyherbal formulations are mainly used to enhance the activity or to counteract the toxic effects of compounds used from the other plants. These formulations may be give synergetic effect, due to presence of multiple ingredients and also may be show synergistic, potentiative, agonistic/antagonistic pharmacological agents within themselves. These formulations having different active constituents with different mechanism of actions which can produce combined action against various complications of diabetes. The aim of the present study is to formulate a polyherbal formulation and screening of its antioxidant potentials in animal modules. The low dose (200mg/kg) of EPHF produced significant increase in hepatic enzymes SOD, CAT and less significant increase in GSH and high dose produced all significant increase in hepatic anti oxidant enzymes. The DPHF at lower dose produced less significant effect in at CAT and SOD but high dose significantly increases them. As well as high dose of PPHF only less significantly increases the hepatic anti oxidant enzymes.