Preparation And In-Vitro Characterization Of Anti-Rheumatic Polyherbal Capsules

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M.Komala, O. Mullaikodi

Abstract

Rheumatoid arthritis is an inflammatory illness that produces chronic inflammation in the joints as a result of synovial hyperplasia and progresses to the point of causing considerable irreversible bone loss. Although a wide number of drugs are available to help control pain and slow the progression of Rheumatoid arthritis, there is currently no known treatment that may completely cure the condition. Herbal drugs can provide an alternative source of treatment for Rheumatoid arthritis sufferers while simultaneously addressing the limitations associated with current allopathic prescription therapy techniques, according to recent research. Boswellia serrate, Zingiber officinale (Ginger), Tribulus terrestris (Tribulus), Camellia sinensis (Green tea), Withania somnifera (Aswagandha) and Piper longum were used in the current investigation to search for an effective and safer alternative formulation. Polyherbal capsules were prepared and evaluated as part of the investigation. FTIR investigations revealed that the extracts and additives used in the creation of granules did not interact with one another, and four formulations (PCS1, PCS2, PCS3, and PCS4) were created utilising the extracts and the additions lactose, starch, and talc (as well as other ingredients). PCS4 had a larger in vitro drug release than other strains, making it a good candidate for additional studies of antiarthritic efficacy in vivo.

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